ChemInform Abstract: ACTION OF GRIGNARD REAGENTS AND ARYLLITHIUM ON 1,1‐DISUBSTITUTED CYCLOHEXANE DERIVATIVES

Abdel-Rahman, Mohamed; Aboul‐Enein, Mohamed Nabil; Tammam, G. H.

doi:10.1002/chin.197828183

Cited by 1 publication

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“…Thiscompound wasprepared according toapublishedmethod [21,22]from morpholine,cyclohexanone and KCN withayield of 81.5 %(m. p. 41 -43°C),IR: 2220 cm -1 ,C =N, str.…”

Section: 221-morpholinocyclohexanecarbonitrilem CC (2)mentioning

confidence: 99%

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Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl)(cyclohexyl)] morpholine as a new phencyclidine derivative in rats

Ahmadi

Khalili

Hajikhani

et al. 2011

Arzneimittelforschung

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Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 77-10-1, PCP, I) and many of its analogues have been synthesized and their pharmacological properties studied. In this research, new methyl morpholine derivative of phencyclidine (1-[1-(4-methylphenyl) (cyclohexyl)]morpholine, Methyl-PCM, III) was synthesized and the acute and chronic pain activities were studied using tail immersion and formalin tests on rats and compared to PCP and PCM (1-(1-phenylcyclohexyl)morpholine, CAS 2201-40-3, PCP-morpholine, II). The results Indicated that Methyl-PCM (III, 6 mg/kg, i.p) produces more analgesic effects in tail immersion test (as a model of acute thermal pain) in comparison with the PCP, PCM and control groups. Meanwhile, this analgesic effect was markedly shown 5-15 min after the compound III application. In formalin test analysis, the acute pain (phase I) could not be affected by any drugs, but the chronic formalin pain (phase II) could be diminished by PCM and especially compound III. The chronic analgesic effect of Methyl-PCM was markedly shown in the late phase of chronic pain.

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“…Thiscompound wasprepared according toapublishedmethod [21,22]from morpholine,cyclohexanone and KCN withayield of 81.5 %(m. p. 41 -43°C),IR: 2220 cm -1 ,C =N, str.…”

Section: 221-morpholinocyclohexanecarbonitrilem CC (2)mentioning

confidence: 99%

“…[11 -13], and incorporation of morpholine groupwithm anypharmacological [15,16]a nd analgesicproperties [17,18]of its derivatives,will havep ronounced effects on the newdrug's activity. Knownp roceduresw ereapplied fort he synthesisof compounds I, II, 1 and 2 withthe appropriatemodifications [21][22][23].…”

Section: 32formalin Testmentioning

confidence: 99%

Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl)(cyclohexyl)] morpholine as a new phencyclidine derivative in rats

Ahmadi

Khalili

Hajikhani

et al. 2011

Arzneimittelforschung

View full text Add to dashboard Cite

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ChemInform Abstract: ACTION OF GRIGNARD REAGENTS AND ARYLLITHIUM ON 1,1‐DISUBSTITUTED CYCLOHEXANE DERIVATIVES

Abstract: Die Cyclohexanderivate (I) und (IIIa) entstehen durch Grignard‐ Reaktionen auf dem angegebenen Weg.

Cited by 1 publication

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Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl)(cyclohexyl)] morpholine as a new phencyclidine derivative in rats

Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl)(cyclohexyl)] morpholine as a new phencyclidine derivative in rats

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