ChemInform Abstract: Alkaloids from the Leaves of Aberia caffra

Sayed, Hanaa M.; Bishay, D. W.; Yousef, S A; Kamel, Mohamed S.; Abdel-Salam, R M

doi:10.1002/chin.200031216

Cited by 2 publications

(5 citation statements)

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“…By comparing the spectral data with that of the published literature (Aliba, Ndukwe, and Ibrahim 2018), the compound was identified as β-sitosterol which is previously isolated from the same plant (Sayed et al 2000).…”

Section: Compound (2)mentioning

confidence: 87%

“…caffra (Warb. ) resulted in the isolation of polyamine alkaloids; aberiamine; and aberiamide, Flavonoids; Luteolin; apigenin; and apigenin-7-O-β-D-glucopyranoside, triterpenes; αand βamyrins, sterols; β-sitosterol; and β-sitosterol-O-β-Dglucopyranoside (Sayed et al 2000), and phenolic glycosides; itoside A; and 4hydorxytremulacin (Stanstrup et al 2010). Biological investigations were performed on the total extract and showed antimicrobial activities (Zaki 1975), Cytotoxic Activity (Moustafa et al 2014) and inhibition of proliferation of Hep G2 cells via apoptosis (El-Menshawi et al 2010).…”

Section: New Dovyalicin-type Spermidine Alkaloid From Dovyalis Cafframentioning

confidence: 99%

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New Dovyalicin-Type Spermidine Alkaloid From Dovyalis Caffra (Warb.); Family: Salicaceae, Cultivated in Egypt

Zaki

2019

Al-Azhar Journal of Pharmaceutical Sciences

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Phytochemical investigations of Dovyalis caffra (leaves and twigs) revealed a new dovyalicin-type spermidine alkaloid, named Dovyalicin G (1); which was identified as (E)-N-(4-(1,5-diazocan-1-yl)butyl)-N-methyltetradec-2-enamide, along with previously isolated β-sitosterol (2) and Hentriacontan-1-ol (3). The structures were established using ESI/MS, EI/MS, 1 H NMR, APT NMR, and two-dimensional NMR experiments. In addition to the biological studies of the different plant extracts including cytotoxicity, topoisomerase II inhibition, antimicrobial, and in-vitro anti-inflammatory activities. Screening of 5-lipoxygenase (5-LOX) and Cyclooxygenase-1 (COX-1) and-2 (COX-2) inhibition to evaluate anti-inflammatory activity were performed. The alkaloid fraction showed good antimicrobial activity against studied microorganisms and remarkable cytotoxic activities against studied cell lines (Besides, total methanolic and petroleum ether extracts). The total methanolic extract showed strong COX-inhibition activity and selectivity toward COX-2, comparing with celecoxib.

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Section: Compound (2)mentioning

confidence: 87%

Section: New Dovyalicin-type Spermidine Alkaloid From Dovyalis Cafframentioning

confidence: 99%

New Dovyalicin-Type Spermidine Alkaloid From Dovyalis Caffra (Warb.); Family: Salicaceae, Cultivated in Egypt

Zaki

2019

Al-Azhar Journal of Pharmaceutical Sciences

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“…Flavonoids Apigenin -Leaves [36] Apigenin-7-O-β-glucoside -Leaves [36] Anthocyanin (mg/kg) 40.2 -90.8…”

Section: Heart Painsmentioning

confidence: 99%

“…Fruit pulp [10] Hesperidin (µg/g) 7.0 -79.0 Fruit pulp [11] Luteolin (µg/g) 2.0 -22.0 Fruit pulp [11] Luteolin -Leaves [36] Quercetin (mg/kg) 30.0 -100.0 Fruit pulp [10,11] Rutin (µg/g) 6.0 -26.0 Fruit pulp [11]…”

Section: Heart Painsmentioning

confidence: 99%

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Traditional Uses, Phytochemical and Pharmacological Properties of Dovyalis caffra

Maroyi

2018

J. Pharm. Nutr. Sci.

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Dovyalis caffra is a valuable indigenous African fruit tree widely cultivated throughout the world. The species is also traditionally used as herbal medicine to treat and manage human and animal diseases. This study reviewed ethnobotanical uses, phytochemical and pharmacological properties of D. caffra. Relevant information on the uses, phytochemistry and pharmacological properties of D. caffra was collected from electronic scienti?c databases such as ScienceDirect, SciFinder, PubMed, Google Scholar, Medline, and SCOPUS. Pre-electronic literature search of conference papers, scientific articles, books, book chapters, dissertations and theses were carried out at the University library. Literature search revealed that D. caffra is used as herbal medicine for amenorrhoea, heart pains, malaria, pain, wounds and as ethnoveterinary medicine. Phytochemical compounds identified from the species include alkaloids, amino acids, fatty acids, flavonoids, hydoxybenzioic acids, hydroxycinnamic acids, hydroxyhydrocinnamic acid, hydroxyphenylacetic acids, organic acids, phenolics, steroids, terpenoids and volatile compounds. Pharmacological studies revealed that D. caffra extracts and compounds have antimicrobial, antioxidant, antischistosomal, nematicidal and cytotoxicity activities. There is need for detailed scientific investigations aimed at elucidating the chemical, nutritional and toxicological properties of D. caffra.

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ChemInform Abstract: Alkaloids from the Leaves of Aberia caffra

Abstract: Alkaloids from the Leaves of Aberia caffra -[isolation and characterization of two new alkaloids (I) and (II) along with some known flavonoids, sterols and terpenes]. -(SAYED, H. M.; BISHAY, D. W.; YOUSEF, S. A.; KAMEL, M. S.; ABDEL-SALAM, R. M.; Indian J. Chem., Sect. B: Org. Chem.

Cited by 2 publications

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New Dovyalicin-Type Spermidine Alkaloid From Dovyalis Caffra (Warb.); Family: Salicaceae, Cultivated in Egypt

New Dovyalicin-Type Spermidine Alkaloid From Dovyalis Caffra (Warb.); Family: Salicaceae, Cultivated in Egypt

Traditional Uses, Phytochemical and Pharmacological Properties of Dovyalis caffra

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