ChemInform Abstract: An Overview on Solubility Enhancement Techniques for Poorly Soluble Drugs and Solid Dispersion as an Eminent Strategic Approach

Jatwani, Sandhiya; Rana, Avtar Chand; Singh, Gurpreet; Aggarwal, Geeta

doi:10.1002/chin.201313244

Cited by 23 publications

(23 citation statements)

References 24 publications

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“…The absorbance of samples was measured at 282 nm for distilled water using a UV spectrophotometer (JASCO V-630, Tsukuba, Japan). 18,19…”

Section: Determination Of Solubilitymentioning

confidence: 99%

Improving the solubility of nevirapine using a hydrotropy and mixed hydrotropy based solid dispersion approach

Madan¹,

Kamate²,

Dua³

et al. 2017

Polim. Med.

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It was concluded that the concept of mixed hydrotropic solid dispersion is a safe, novel and cost-effective technique for enhancing the bioavailability of poorly water-soluble drugs by dissolving the drug in a nonionized form. The enhancement in solubility of nevirapine using hydrotropy is a clear indication of its potential to be used in the future for other poorly water-soluble drugs in which low bioavailability is a major concern.

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“…The absorbance of samples was measured at 282 nm for distilled water using a UV spectrophotometer (JASCO V-630, Tsukuba, Japan). 18,19…”

Section: Determination Of Solubilitymentioning

confidence: 99%

Improving the solubility of nevirapine using a hydrotropy and mixed hydrotropy based solid dispersion approach

Madan¹,

Kamate²,

Dua³

et al. 2017

Polim. Med.

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“…Nevertheless, oral formulations are being (Modi, 2012;Shinde, 2012) developed keeping in consideration the basic biological and pharmaceutical approaches of drug delivery via the oral route. Now a days as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use and some limitations of conventional dosage forms, as these have to be administered several times a day as to maintain a therapeutically effective plasma level of drug, which is a major drawback in terms of patient compliance (Jatwani et al, 2012). Hence, change in the operation is a suitable and optimized way to make the same drug more effective by slight alteration in the drug delivery (Singh et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

<I>In Vitro</I> Evaluation of Matrix Tablets for Oral Extended Release of Poorly Water-Soluble Glibenclamide Using Combination of Hydrophilic and Hydrophobic Matrix Formers

Kumar¹,

Sharma²,

Bhandari³

2014

j pharmaceut sci pharmacol

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Aim of the present study was to prepare and evaluate extended-release matrix tablets of Glibenclamide using hydrophilic polymer Polyvinyl pyrrollidone alone or in combination with hydrophobic polymer ethyl cellulose. Release kinetics was evaluated by using United States Pharmacopeia (USP)-22 type I dissolution apparatus. The higher rate and extent of Glibenclamide (GLB) released from Tablet prepared by dissolving method (TDM) solid dispersion tablets is due to hydrostatic interaction of PVP. With the release of surface drug, numerous pores and channels are generated through which dissolution media enters into the tablet and further elevates the rate and extant of GLB release rate. On the other hand, water soluble excipients such as lactose results in as increase in the drug release rate due to an increment in porosity (due to the dissolution of the drug). Moreover, presence of Ethyl cellullose played a meaningful role in controlling the drug release for 12 hours. Kinetics treatment revealed that dissolution efficiency up to 12 h is higher in TDM formulation. The kinetics showed that the release of drug followed Zero order kinetics. In conclusion, the results suggest that the developed extended-release tablets of Glibenclamide could perform therapeutically better than conventional dosage forms, leading to improve efficacy and better patient compliance.

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“…Almost more than 90 % drugs are orally administered. Drug absorption sufficient and reproducible bioavaiblity, pharmacokinetic profile of orally administered drug substances is highly dependent on solubility of that compound in aqueous medium [4] .…”

Section: Introductionmentioning

confidence: 99%

A Review - Solubility Enhancement of Poorly Water Soluble Drugs

Patil¹,

Shirkhedkar²

2016

IJAPB

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Improvement in solubility of drug is a very formidable task in drug development. Approximately 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility and dissolution properties of drugs play a pivotal role in the process of formulation development. Among all newly discovered chemical entities most of the drugs are lipophilic and fail to reach market due to their poor water solubility. The ability to deliver poorly soluble drugs will grow in significance in the coming years. Similarly, generic drug manufacturers will need to exercise economically efficient methods of delivery as more low solubility drugs go off patent, in order to maintain a competitive edge and sufficiently compete as profit margins shrink in this price-sensitive industry. For this reason solubility enhancement is an important in future.

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ChemInform Abstract: An Overview on Solubility Enhancement Techniques for Poorly Soluble Drugs and Solid Dispersion as an Eminent Strategic Approach

Abstract: Review: 87 refs.

Cited by 23 publications

References 24 publications

Improving the solubility of nevirapine using a hydrotropy and mixed hydrotropy based solid dispersion approach

Improving the solubility of nevirapine using a hydrotropy and mixed hydrotropy based solid dispersion approach

<I>In Vitro</I> Evaluation of Matrix Tablets for Oral Extended Release of Poorly Water-Soluble Glibenclamide Using Combination of Hydrophilic and Hydrophobic Matrix Formers

A Review - Solubility Enhancement of Poorly Water Soluble Drugs

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