ChemInform Abstract: Analogues of Carbacholine: Synthesis and Relationship Between Structure and Affinity for Muscarinic and Nicotinic Acetylcholine Receptors.

Abstract

1996 carbamic acid derivatives carbamic acid derivatives (acyclic compounds) P 0480 24 -104 Analogues of Carbacholine: Synthesis and Relationship Between Structure and Affinity for Muscarinic and Nicotinic Acetylcholine Receptors. -A series of acyclic (cf. (V)) and heterocyclic analogues (cf. (XI), ( XVII)) of carbacholine are synthesized and their pharmacological profiles are estimated on the basis of ligand receptor binding studies. -(SOEKILDE, B.; MIKKELSEN, I.; STENSBOEL, T. B.; ANDERSEN, B.; EBDRUP, S.; KROGSGAARD-LARSEN, P.; FALCH, E.; Arch. Pharm. (Weinheim, Ger.) 329 (1996) 2, 95-104; PharmaBiotec Res. Cent., Dep. Med. Chem., Royal Dan. Sch. Pharm., DK-2100 Copenhagen, Den.; EN)