ChemInform Abstract: Antibacterial and Antimycotics. Part 1. Synthesis and Activity of 2‐Pyrazoline Derivatives.

Nauduri, Dhananjaya; Reddy, Gopu Bala Show

doi:10.1002/chin.199906114

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2011

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“…Pyrazoline derivatives of chalcones have been reported to possess a widespread range of biological activities like antibacterial (Nauduri and Reddy, 1998), antifungal (Azarifar and Shaebanzadeh, 2002), antidepressant (Bilgin et al, 1993), antitumor (Taylor and Patel, 1992), antimicrobial (Ramalingham et al, 1977), anti-inflammatory, molluscicidal activity (Barsoum et al, 2006), antiamoebic (Budakoti et al, 2006), anticonvulsant activities (Ozdemir et al, 2007). One of the most famous pyrazole-based drugs used as a non-steroidal anti-inflammatory drug (NSAID) is celecoxib ( Fig.…”

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confidence: 99%

Novel quinolyl-thienyl chalcones and their 2-pyrazoline derivatives with diverse substitution pattern as antileishmanial agents against Leishmania major

et al. 2011

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A series of twenty-two new pyrazoline derivatives was prepared from quinoline-based chalcones which in turn were synthesized by condensing formylquinolines with diverse acetylthiophenes. The titled compounds were characterized by spectroscopic techniques (NMR, IR and MS) and elemental analysis. All the compounds were screened for antileishmanial activities. Compounds 1e, 1f, 2a, 2c, 2d, 2g, 2k, and 4a were found potentially active antileishmanial agents. Bioassay results show that the type and positions of the substituents seem to be critical for their antileishmanial activities.

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