ChemInform Abstract: Antiinflammatory Activity of N‐Naphthoyl D‐Alanine in vivo.

Abstract

Antiinflammatory activity X 0130Antiinflammatory Activity of N-Naphthoyl D-Alanine in vivo. -Title compound (I) expresses antiinflammatory activity in a cyclooxygenases-inhibiting manner by reproducing the zigzag structure of naproxen. The zigzag structure, especially the planarity between N4-C5 derived from the double bond nature of the amide function, is of importance. -(GOTO*, M.; KATAOKA, H.; ARAYA, Y.; KAWASAKI, M.; OYAMA, K.-I.; SEMMA, M.; ITO, Y.; ICHIKAWA, A.; Bull. Korean Chem. Soc. 30 (2009) 4, 781-782; Dep. Chem. Biochem. Eng., Toyama Natl. Coll. Technol., Hongo, Toyama 939, Japan; Eng.) -H. Hoennerscheid