ChemInform Abstract: ANTIVIRAL ACTIVITY OF TETRAHYDRO‐2(1H)‐PYRIMIDINONES AND RELATED COMPOUNDS

As, Galabov; Velichkova, E; Karparov, A; Sidzhakova, D.; Danchev, D; Чакова, Н. Н.

doi:10.1002/chin.198419231

Cited by 14 publications

(14 citation statements)

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“…2I) which showed antiviral effect in vitro and in vivo against influenza А (Н1N1, Н2N2, Н3N2, Н7N7) and B type. Mopyridone alters the contact of M1 protein with the lipid bilayer of the envelope and thus interrupts the morphogenesis and assembly of the viral particles (20,23,86).…”

Section: м1 Inhibitorsmentioning

confidence: 99%

Chemotherapy of Influenza: Current and Novel Approach

Simeonova

Galabov

2011

Biotechnology & Biotechnological Equipment

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Section: м1 Inhibitorsmentioning

confidence: 99%

Chemotherapy of Influenza: Current and Novel Approach

Simeonova

Galabov

2011

Biotechnology & Biotechnological Equipment

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“…Noteworthy the inhibitory effect of the compound on replication of alphaviruses Semliki forest (SFV), Sindbis (SV) and Western equine encepha lomyelitis (W EEV) (Galabov et al, 1984;Karparov et al, 1986). Moreover, mopyridone was highly efficient in vivo when administered intrave nously or subcutaneously in mice infected with SFV and SV, and a significant protection was re corded even at massive virus inocula (Karparov et al, 1985).…”

Section: Introductionmentioning

confidence: 97%

“…l-(4-Morpholinomethyl)-tetrahydro-2(lH)-pyrimidinone (mopyridone, MCU) is an antiviral sub stance, synthesized by Sidzhakova et al (1982), which manifested a marked activity against alphaand orthomyxoviruses (Galabov et al, 1984(Galabov et al, ,1994. Noteworthy the inhibitory effect of the compound on replication of alphaviruses Semliki forest (SFV), Sindbis (SV) and Western equine encepha lomyelitis (W EEV) (Galabov et al, 1984;Karparov et al, 1986).…”

Section: Introductionmentioning

confidence: 98%

Inhibitory Effect of a Cyclic Urea Derivative on Rubella Virus Replication

Galabov

Mihneva²,

Hadjiathanassova³

et al. 2000

Zeitschrift Für Naturforschung C

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1-(4-Morpholinomethyl)-tetrahydro-2(1H)-pyrimidinone (mopyridone) exhibited a marked activity against rubella virus (Judith and RA27/3 strains), a MIC50 value of 0.9 μᴍ and selectivity ratio of 557.7 been found in the case of Judith strain. These data, in addition to the previous ones about its anti-alphavirus effects suggest the compound to be considered as a broad spectrum inhibitor of togavirus replication.

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“…Pyrimidine derivatives have become the subject of great interest because of their diverse biological and medical activities [15][16][17][18]. Dihydropyrazolo [1,5-c]pyrimidines have high physiological activity, the most important being cardiovascular activity [19].…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical studies on the reactions of 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-one/-thione compounds with ethyl acetoacetate

et al. 2010

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The reaction of 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-one/-thione (1a,b) with ethyl acetoacetate (EA) afforded moderate to good yields (59-63%) of ethyl 2-methyl-4-(4-methylbenzoyl)-5-(4-methylphenyl)-7-oxo/-thioxo-3,3a-dihydropyrazolo[1,5-c]pyrimidine-3-carboxylate (2a,b). The newly synthesized compounds were characterized by elemental analyses, IR, 1 H and 13 C NMR spectral data. All were compared with their previous analogues. The reaction mechanism of 1 with EA was studied by means of the B3LYP/6-31G(d,p) method. In addition, for reactants Fukui functions were performed using the data calculated with the Becke3-Lee-Yang-Parr (B3LYP) hybrid function.

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ChemInform Abstract: ANTIVIRAL ACTIVITY OF TETRAHYDRO‐2(1H)‐PYRIMIDINONES AND RELATED COMPOUNDS

Cited by 14 publications

References 0 publications

Chemotherapy of Influenza: Current and Novel Approach

Chemotherapy of Influenza: Current and Novel Approach

Inhibitory Effect of a Cyclic Urea Derivative on Rubella Virus Replication

Experimental and theoretical studies on the reactions of 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-one/-thione compounds with ethyl acetoacetate

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