ChemInform Abstract: Application of the Heck Reaction for the Synthesis of 1‐Alkoxyisoquinoline‐3‐carboxylic Acids Esters.

Abstract

Application of the Heck Reaction for the Synthesis of 1-Alkoxyisoquinoline-3-carboxylic Acids Esters. -The synthesis of isoquinoline-3-carboxylic acid derivatives via Heck reaction and subsequent cyclization is studied. Surprisingly, 1-alkoxyisoquinoline-3-carboxylic acid esters (VI) and (IX) are obtained with acrylate (V) as Heck reactant. The underlying mechanism remains unclear. -(TURE, A.; RUBINA, K.; ROZHKOV, E.; KAUSS*, V.; Chem. Heterocycl.