ChemInform Abstract: Applications of the Spiroannulation of Tetralins with Alkynes; Towards New Anti‐Estrogenic Compounds.

Abstract

fused phenylcycloalkyl derivatives fused phenylcycloalkyl derivatives (rings with 3, 4, 7 or more members) Q 1040 -087Applications of the Spiroannulation of Tetralins with Alkynes; Towards New Anti-Estrogenic Compounds. -With a view to obtaining biologically interesting compounds the derivatives such as (VI) are synthesized. In a model system it is shown that a similar reaction to derivatives such as (VI) with ethyne or mono-or bistrimethylsilylethyne is not possible or gives very low yield with no selectivity. Therefore in a second approach the parent carbocycle (IX) missing the aryl substituent is developed. -(BOYLE, F. T.; HARES, O.; MATUSIAK, Z. S.; LI, W.; WHITING, D. A.; J.