ChemInform Abstract: Asymmetric Aldol Reaction of α,α‐Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers.

Abstract

Asymmetric Aldol Reaction of ,-Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers. -The aldol reaction of aldehydes (I) and (V) with ethyl glyoxylate polymer affords the corresponding aldol adducts with moderate diastereoselectivities and low to good enantioselectivities. -(HAYASHI*, Y.; SHOMURA, H.; XU, Q.; LEAR, M. J.; SATO, I.; Eur. J. Org. Chem. 2015, 20, 4316-4319, http://dx.doi.org/10.1002/ejoc.201500585 ; Dep. Chem., Grad. Sch. Sci., Tohoku Univ., Aoba, Sendai 980, Japan; Eng.) -Mais 47-024