ChemInform Abstract: Asymmetric Formation of tert‐Alkylamines from Serinols by a Dual Function Catalyst.

Abstract

Catalyst. -A series of enantiopure oxazolidinones (III), useful tert.-alkylamine building blocks, is prepared in an one-pot manner by intramolecular desymmetrization of serinols (I) by a copper-catalyzed cyclization and a subsequent kinetic resolution of enantiomerically enriched hydroxymethyl-oxazolidinone intermediates (75-80% e.e.) by a benzoylation. -(YOU, Y. S.; KIM, T. W.; KANG*, S. H.; Chem. Commun. (Cambridge) 49 (2013) 83, 9669-9671, http://dx.