ChemInform Abstract: Asymmetric Palladium‐Catalyzed Umpolung Cyclization of Allylic Acetate‐Aldehyde Using Formate as a Reductant.

Abstract

Asymmetric Palladium-Catalyzed Umpolung Cyclization of Allylic Acetate-Aldehyde Using Formate as a Reductant. -The first example of an enantioselective umpolung cyclization of allylic acetates or aldehydes is described. The highly enantioselective cyclization is suitable for the synthesis of various heterocycles and spiro--carbocycles otherwise hardly accessible. -(TSUKAMOTO*, H.; KAWASE, A.; DOI, T.; Chem. Commun. (Cambridge) 51 (2015) 38, 8027-8030, http://dx.doi.org/10.1039/C5CC02176F ; Grad. Sch. Pharm. Sci., Tohoku Univ., Aoba, Sendai 980, Japan; Eng.) -R. Staver 36-037