ChemInform Abstract: ASYMMETRIC SYNTHESIS BY CHIRAL RUTHENIUM COMPLEXES. V. HOMOGENEOUS REDUCTION OF KETONES: TRANSFER AND PRESSURE HYDROGENATION IN THE PRESENCE OF H4RU4(CO)8((‐)‐DIOP)2

Bianchi, Mario; Matteoli, Ugo; Menchi, Gloria; Frediani, Piero; Pratesi, Stefano; Piacenti, Franco; Botteghi, C.

doi:10.1002/chin.198106188

Cited by 10 publications

(3 citation statements)

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“…Two decades later, Chowdhury and Bäckvall found that the [RuCl 2 (PPh 3 ) 3 ]-promoted reaction was accelerated by 10 3 –10 4 times upon adding a catalytic amount of NaOH. In the early 1980s, the first reports of the Ru-catalyzed asymmetric TH emerged. ,, Since then, asymmetric TH (ATH) has received significant attention as an essential branch of TH. Asymmetric hydrogenation (AH) is an important process in the fragrance and pharmaceutical industries, , culminating with the seminal work by Kagan and the award of the Nobel Prize to Noyori and Knowles for their contribution to the field in 2001. − ATH based on late transition-metal catalysts has proven to be among the most powerful methods for asymmetric reduction of various unsaturated substrates to produce chiral compounds. ,,,,− This is due to the excellent stereoselectivities provided by these catalysts, the availability of various hydrogen sources, operational simplicity, and the use of readily accessible and little sensitive catalysts.…”

Section: Introductionmentioning

confidence: 99%

“…In the early 1980s, the first reports of the Rucatalyzed asymmetric TH emerged. 6,34,35 Since then, asymmetric TH (ATH) has received significant attention as an essential branch of TH. Asymmetric hydrogenation (AH) is an important process in the fragrance and pharmaceutical industries, 36,37 culminating with the seminal work by Kagan and the award of the Nobel Prize to Noyori and Knowles for their contribution to the field in 2001.…”

Section: Introductionmentioning

confidence: 99%

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The Golden Age of Transfer Hydrogenation

2015

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Golden Age of Transfer Hydrogenation

2015

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“…Ru-catalyzed ATH of CO bonds was well established in the 1980s. , Acetophenone had always been chosen as the standard substrate to evaluate the catalytic efficiency and the enantioselectivity of a newly developed catalyst. We summarize Ru-catalyzed ATH of acetophenone with tridentate ligands in Scheme .…”

Section: Transition Metal-catalyzed Hydrogenation Reactions With Chir...mentioning

confidence: 99%

Chiral Tridentate Ligands in Transition Metal-Catalyzed Asymmetric Hydrogenation

2021

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Asymmetric hydrogenation (AH) of double bonds has been one of the most effective methods for the preparation of chiral molecules and for the synthesis of important chiral building blocks. In the past 60 years, noble metals with bidentate ligands have shown marvelous reactivity and enantioselectivity in asymmetric hydrogenation of a series of prochiral substrates. In recent years, developing chiral tridentate ligands has played an increasingly important role in AH. With modular frameworks and a variety of functionalities on the side arms, chiral tridentate ligand complexes enable both reactivities and stereoselectivities. Although great achievements have been made for noble metal catalysts with chiral tridentate ligands since the 1990s, the design of chiral tridentate ligands for earth abundant metal catalysts has still been in high demand. This review summarizes the development of chiral tridentate ligands for homogeneous asymmetric hydrogenation. The philosophy of ligand design and the reaction mechanisms are highlighted and discussed as well.

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