ChemInform Abstract: Asymmetric Synthesis of β²‐Amino Acids: 2‐Substituted‐3‐aminopropanoic Acids from N‐Acryloyl SuperQuat Derivatives.

Abstract

Amino acids U 0400Asymmetric Synthesis of β 2 -Amino Acids: 2-Substituted-3-aminopropanoic Acids from N-Acryloyl SuperQuat Derivatives. -Based on N-acryloyl SuperQuat compound (I), conjugate addition of lithium amides followed by stereoselective enolate functionalization allows access to (S)-2-alkyl β 2 -amino acids (to be continued). -(BEDDOW, J. E.; DAVIES*, S. G.; LING, K. B.; ROBERTS, P. M.; RUSSELL, A. J.; SMITH, A. D.; THOMSON, J. E.; Org.