ChemInform Abstract: Azinyl Sulfides. Part 52. 1,4‐Dihydro‐1‐methyl‐4‐thioxo‐3‐quinolinesulfonamides.

Abstract

Azinyl Sulfides.Part 52. 1,4-Dihydro-1-methyl-4-thioxo-3quinolinesulfonamides.-A number of the title sulfonamides (III) are prepared and evaluated for their antihypertensive activity. -(SKRZYPEK, L.; FOLWARCZNA, J.; JANIEC, W.; KACZMARCZYK-SEDLAK, I.; MASLANKIEWICZ, A.; PYTLIK, M.; Pol.

From 2,3-, 2,6-, 3,4- and 4,6-Dichloroquinolines to Isomeric Chloroquinolinesulfonyl Chlorides

“…This should lead to x,y-di(chlorosulfonyl)quinolines (4). For this purpose dithiolates 2A were acidified to non-isolated dithiols 2T, which were then oxidatively chlorinated with sodium hypochlorite in conc.…”

“…2-Chloro-and 4-chloroquinoline moieties, 1 as well as quinolinesulfonyl chloride units 2,3,4,5 give broad access to further functionalization of quinolines. Co-occurrence of both functional groups in one quinoline molecule broaden the above potential, as was shown for 4-chloro-3-quinolinesulfonyl chloride (5b) 4,5 and 2-chloro-6-quinolinesulfonyl chloride (5c) 6 in studies directed at the preparation of biologically active compounds.…”

“…Co-occurrence of both functional groups in one quinoline molecule broaden the above potential, as was shown for 4-chloro-3-quinolinesulfonyl chloride (5b) 4,5 and 2-chloro-6-quinolinesulfonyl chloride (5c) 6 in studies directed at the preparation of biologically active compounds. [1][2][3][4][5][6] The 3-or 7-chlorosulfonyl-4-chloroquinolines (5b,e), 4,5,8 8chlorosulfonyl-4-chloroquinolines, 7 4-chlorosulfonyl-7-chloroquinoline (8e), 8 and 2-chloro-6-quinolinesulfonyl chloride (5c), 6 are well known but only the 4,7-isomers 5e and 8e were prepared from the respective dichloroquinoline (1e). 8 Azinesulfonyl chlorides could be directly obtained by oxidative chlorination of thioazines -thiols 8,9,10 disulfides, 8,9 benzylsulfides 5,11 with a thio substituents at non-aza-activated positions.…”