ChemInform Abstract: Bioactive C15 Acetogenins from the Red Alga Laurencia obtusa.

Ayyad, Seif‐Eldin N.; Al-Footy, Khalid O.; Alarif, Walied M.; Sobahi, Tariq R.; Bassaif, Salim Ahmed; Makki, Mohamed S. T.; Asiri, Abdullah M.; Halawani, Amani Yahya Al; Badria, Adel F.; Badria, Farid A.

doi:10.1002/chin.201211213

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“…Extensive fractionation of the n-hexane extract of Laurencia majuscula, employing different chromatographic techniques, led to isolation of eight metabolites (1-8) namely: 4,10-dibromo-3chloro-7(14)-chamigrene (1); α-isobromocuparene (2); (12E)-cis-maneonene A (3); (12Z)-cismaneonene D (4); (12E)-cis-maneonene E (5); bromlaurenidificin (6); jeddahenyne A (7) and cuparen-3-ol (8). The structures of these compounds were elucidated via interpretation of their spectra, including 1D and 2D as well as NMR and MS, and comparison with reported data [9][10][11][12][13][14].…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic effect of acetogenins and sesquiterpenes obtained from the Red alga Laurencia majuscula

Alorfi¹,

Ghandourah²,

Turki³

2020

Trop. J. Pharm Res

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Purpose: To evaluate the cytotoxicity of n-hexane extract and its metabolites obtained from the red alga, Laurencia majuscula, against three cancer cell lines HCT-116 (colon cancer), PC-3 (prostate cancer) and HepG2 (liver cancer) cells; and to identify the phytochemical compound(s) involved. Methods: Solvent extraction, thin layer chromatography, aluminum oxide column chromatography, and preparative thin layer chromatography (PTLC) were employed for isolating pure compounds from nhexane extract of Laurencia majuscula. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) measurements were used for structural elucidation of the compounds. The cytotoxicity of the nonpolar extract and isolated compounds were evaluated against HCT, PC-3, and HepG2 cells using MTT assay, relative to the standard cytotoxic drug (cisplatin). Results: Three sesquiterpenes (1, 2 and 8), and five acetogenins (3-7) were isolated from the n-hexane extract. The n-hexane extract showed higher potent cytotoxic effect than sesquiterpenes and the acetogenins (3-7). Conclusion: These results indicate that the n-hexane extract of Laurencia majuscula exerts significant cytotoxicity against HCT-116, PC-3 and HepG2 cell lines, thus suggesting that the plant extract may be effective chemotherapeutic agents for the management of colon, postrate and liver cancer. Keywords: Red Sea alga, Rhodomelaceae, Polyketides, Terpenes, Anticancer

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