ChemInform Abstract: BIOLOGICAL ACTIVITY OF SOME 2‐AMINO‐4,5,6,7‐TETRAHYDROBENZO(B)‐THIOPHENES AND THEIR DERIVATIVES

Ramanathan, J. D.; Namboothiri, D G; Shah, G. F.; Radhakrishnan, Anbarasi; Mehta, H. J.; Padhya, A. C.

doi:10.1002/chin.197906151

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IRspectra were measured on a Unicam SP1200 spectrometer using the KBr wafer technique. 1 °C, 2-Amino-4,5,6,7-tetrahydro [1]benzothiophene-3-carbonitrile(1a), 8 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile (4), 9 substituted benzylidenemalononitriles (2), 10 and acetylenic esters 11 and ketones 12 (6) were prepared according to literature methods.…”

Section: Methodsmentioning

confidence: 99%

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones

Youssef

2009

Journal of Chemical Research

View full text Add to dashboard Cite

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile (1a) with substituted benzylidenemalononitriles gave 4-amino-2-(1-cyano-2-arylvinyl)benzothieno[2,3- d]pyrimidine derivatives (3) as ( E,Z)-mixtures and in one case (2c) as separated ( Z)- and ( E)-isomers. Similar treatment of 6-amino-1,4-dihydro-3-methyl-1,4-diphenyl-pyrano[2,3- c]pyrazole-5-carbonitrile (4) yielded similarly-formed pyrazolopyranopyrimidine derivatives (5a, b) as ( Z)-and ( E)-stereoisomers. Attempted acetylation of the aminobenzothienopyrimidines resulted in degradation of the pyrimidine ring and the formation of N-(3-cyano-4,5,6,7-tetrahydro[1]benzothien-2-yl)acetamide (1b). Treatment of 4 with acetylenic esters and ketones (6a-d) afforded the ( Z)-substituted enaminopyrano[2,3- c]pyrazole derivatives. Reacting 1a with aroyl phenyl acetylenes gave by Michael addition the enamino-ketones (8a-c).

show abstract

Section: Methodsmentioning

confidence: 99%

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones

Youssef

2009

Journal of Chemical Research

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: BIOLOGICAL ACTIVITY OF SOME 2‐AMINO‐4,5,6,7‐TETRAHYDROBENZO(B)‐THIOPHENES AND THEIR DERIVATIVES

Abstract: Aus den Kondensationsprodukten von Cyclohexanon (I) mit den CH‐aciden Verbindungen (II) werden mit Schwefel nach der Gewald‐Reaktion die Aminothiophene (IV) hergestellt.

Cited by 1 publication

References 0 publications

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones

Contact Info

Product

Resources

About