ChemInform Abstract: Biologically Active Glycosides from Asteroidea. Part 40. Two New Gangliosides, Acanthagangliosides I and J, from the Starfish Acanthaster planci.

Abstract

A new ganglioside molecular species named AG-1 has obtained from the whole body of starfish Acanthaster planci (crown of thorns). The structure of this ganglioside have been elucidated by enzymatic hydrolysis with the endo-type glycosidase. Enzymatic hydrolysis gave an oligosaccharide and ceramides, quantitatively. The oligosaccharide moiety was determined mainly using 2D-NMR experiments as β-Fucf-(1Ǟ4)-α-Galp-(1Ǟ4)-α-NeuAc-(2Ǟ3)-β-Galp-(1Ǟ4)-Glcp.

Biologically active gangliosides from echinoderms

“…Another characterization of the gangliosides from sea cucumber is the existence of Fuc-contained oligosaccharide moieties. Although a Fuc-contained ganglioside has been obtained from the starfish A. planci [18], such gangliosides as CEG-3, HPG-1 and HLG-3 [19] from H. leucospilota are found in many sea cucumber species. On the other hand, the sugar moiety of SJG-2 [20] from Stichopus japonicus is different from another sea cucumber gangliosides and quite unique, namely, three sialic acids exist at the terminal and inside of amino sugar-contained oligosaccharide (Fig.…”

Astonishing diversity of natural surfactants: 4. Fatty acid amide glycosides, their analogs and derivatives

“…Two new ganglioside molecular species, named acanthaganglioside I 158 and acanthaganglioside J 159, have been isolated from the whole body of the crown-of-thorns starfish Acanthaster planci (138). The N-acyl groups on residue are C22:0 and C24:0 FA, whereas the fatty alcohol is straight (C16:0) in both gangliosides.…”