ChemInform Abstract: Carbamate Synthesis by Solid‐Base Catalyzed Reaction of Disubstituted Ureas and Carbonates.

Gupte, Sunil P.; Shivarkar, Anand B.; Chaudhari, Raghunath V.

doi:10.1002/chin.200214098

Cited by 3 publications

(2 citation statements)

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“…Other uses of carbamates are well-known. Particularly, the employment of carbamates in various industries as agrochemicals, in the polymer industry, and also in peptide syntheses. − In addition, among the various amine-protecting groups, carbamates are commonly used to enhance their chemical stability toward acids, bases, and hydrogenation…”

Section: Organic Carbamates: Applications and Chemical And Metabolic ...mentioning

confidence: 99%

Organic Carbamates in Drug Design and Medicinal Chemistry

2015

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The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many carbamate derivatives are specifically designed to make drug-target interactions through their carbamate moiety. In this review, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent application of carbamates in drug design and medicinal chemistry.

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Section: Organic Carbamates: Applications and Chemical And Metabolic ...mentioning

confidence: 99%

Organic Carbamates in Drug Design and Medicinal Chemistry

2015

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“…Lemaire and coworkers have reported [157] Chaudhari and coworkers have reported [158] an efficient protocol for the synthesis of carbamates 6 through the reaction of various carbonates (100,120) Selva and workers have reported [160] an efficient synthesis of carbamates 6 from primary aliphatic amines 4 with dialkyl carbonates (100 & 124) in supercritical CO 2 (Scheme 102). Later on, Christention and coworkers have reported [162] the synthesis of carbamate protected polyamines (130, 131, 132, 134, 135, 136) using alkyl phenyl carbonates (126, 127, 128).…”

Section: 5d Organic Carbonates and Carbon Dioxidementioning

confidence: 97%

Recent Developments on the Carbamation of Amines

Chaturvedi

2011

COC

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Organic carbamates represent an important class of compounds showing various interesting properties. They find wide utility in various areas as pharmaceuticals, agrochemicals (pesticides, herbicides, insecticides, fungicides etc.), intermediates in organic synthesis, protection of amino group in peptide chemistry, and as linker in combinatorial chemistry etc. Classical synthesis of carbamates involves use of harmful reagents such as phosgene, its derivatives and carbon monoxide. Recently, various kinds of synthetic methods have been developed for the synthesis of organic carbamates. In the present review, I would like to highlight the recent developments on the synthesis of organic carbamates using variety of reagents.

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Stereospecific Synthesis of cis/trans-dicarbamates

Kelebekli

2024

Ordu Üniversitesi Bilim Ve Teknoloji Dergisi

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The efficient synthesis of a new class of allylic cis/trans-dicarbamates are described. Allylic diols as key intermediates of the targeted compounds were prepared in a facile way, starting from p-benzoquinone. Reaction of allylic diol compounds with p-TsNCO resulted in the formation of cis/trans-dicarbamate groups. The structure of cis/trans-dicarbamates were determined by 1H-NMR, 13C-NMR, FT-IR and elemental analysis techniques.

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ChemInform Abstract: Carbamate Synthesis by Solid‐Base Catalyzed Reaction of Disubstituted Ureas and Carbonates.

Cited by 3 publications

References 1 publication

Organic Carbamates in Drug Design and Medicinal Chemistry

Organic Carbamates in Drug Design and Medicinal Chemistry

Recent Developments on the Carbamation of Amines

Stereospecific Synthesis of cis/trans-dicarbamates

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