ChemInform Abstract: Catalytic Enantioselective Passerini Three‐Component Reaction.

Abstract

Enantioselective syntheses O 0031Catalytic Enantioselective Passerini Three-Component Reaction. -An efficient asymmetric three-component reaction of aldehydes (I), isocyanides (II) and carboxylic acids (III) is presented using a chiral salen-derived Lewis acid catalyst. The product amides (IV) and (VI) are obtained with good enantioselectivity for a wide range of substrates. -(WANG, S.-X.; WANG*, M.-X.; WANG, D.-X.; ZHU, J.; Angew.