ChemInform Abstract: Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum.

Abstract

Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum. -Fifteen new triterpenoids, including terreolides A-C (I) possessing a unique trioxaspiroketal system and terreolides D-F (II) having an unprecedented carbon skeleton, are isolated from the title mushroom. Two abundant compounds, saponaceolide B (IIIb) and saponaceolide M (IVc), display acute toxicity and increase serum CK levels in mice. -(YIN, X.; FENG, T.; SHANG, J.-H.; ZHAO, Y.-L.; WANG, F.; LI, Z.-H.; DONG, Z.-J.; LUO, X.-D.; LIU*, J.-K.; Chem. -Eur. J. 20 (2014) 23, 7001-7009, http://dx.

Is the Yellow Knight Mushroom Edible or Not? A Systematic Review and Critical Viewpoints on the Toxicity of Tricholoma equestre

“…In spite of the fact that the first cases of human poisoning with T. equestre were documented in scientific literature over 15 years ago, as yet no causative toxin has been identified and isolated. Instead, evidence for causing rhabdomyolysis has been characterized in other mushrooms such as Russula subnigricans Hongo (cycloprop‐2‐ene carboxylic acid) or Tricholoma terreum (saponaceolide B7 and saponaceolide M13) (Matsuura et al., ; Yin et al., ). A study by Yin et al., also notes that myotoxic saponaceolides have not been identified in T. equestre but states that an extract obtained from this mushroom displayed toxicity of a distinctively different mechanism of action.…”

“…Instead, evidence for causing rhabdomyolysis has been characterized in other mushrooms such as Russula subnigricans Hongo (cycloprop‐2‐ene carboxylic acid) or Tricholoma terreum (saponaceolide B7 and saponaceolide M13) (Matsuura et al., ; Yin et al., ). A study by Yin et al., also notes that myotoxic saponaceolides have not been identified in T. equestre but states that an extract obtained from this mushroom displayed toxicity of a distinctively different mechanism of action. However, unexpectedly, the description of the methodology and presentation of the results of this study essentially delivers no information on the collected T. equestre specimens, their identification, extract preparation, analytical data nor experimental studies allegedly performed to assess their toxicity (Yin et al., ).…”

“…A study by Yin et al., also notes that myotoxic saponaceolides have not been identified in T. equestre but states that an extract obtained from this mushroom displayed toxicity of a distinctively different mechanism of action. However, unexpectedly, the description of the methodology and presentation of the results of this study essentially delivers no information on the collected T. equestre specimens, their identification, extract preparation, analytical data nor experimental studies allegedly performed to assess their toxicity (Yin et al., ). Due to the publicity that this research has generated, information that T. equestre supposedly contain some toxin has been spread, potentially adding to the conviction that this mushroom should be considered as poisonous.…”

Dažniausi Apsinuodijimo Grybais Sindromai Ir Inkstų Pažeidimai

“…Ūminis inkstų nepakankamumas atsiranda dėl intrarenalinės vazokonstrikcijos, tiesioginio ir išeminio inkstų kanalėlių pažeidimo ir obstrukcijos mioglobinu [28]. Taip pat nuodingosios ūmėdės toksinas galimai sukelia kardiovaskulinės sistemos komplikacijas -ūmi kairiojo skilvelio sistolinė disfukcija sukelia kardiogeninį šoką [29,35,36].…”

“…Jei inkstų ar kepenų funkcija dekompensuoja, pacientai turėtų būti nukreipti į hemodializę arba inkstų ar kepenų tranplantaciją [41]. Esant kardiogeniniam šokui, gali būti svarstomas intraaortinis balionas kaip galutinis gydymo variantas [35].…”