ChemInform Abstract: Chemical Constituents Isolated from Andrographis paniculata

Abstract

Chemical Constituents Isolated from Andrographis paniculata -[isolation and structure determination of six diterpenoides of type (I)/(II) and three diterpenoidal glycosides]. -(KULYAL*, P.; TIWARI, U. K.; SHUKLA, A.; GAUR, A. K.; Indian J.

Bioassay Guided Isolation of Antibacterial Compounds from <i>Andrographis paniculata</i>

“…The characteristic exocyclic methylene protons for AB-2 diterpenoids were observed at δ 4.595 (brs, 1H) and 4.455 (brs, 1H) in 1 HNMR as well as at δ 108.86 in 13 C, respectively. The 1 H-and 13 C-NMR (in CDCl 3 ) spectra of AB-2 suggested a diterpenoid compound with a structure similar to that of 14-deoxyandrographolide (Poonam et al, 2010) (Fig. 2).…”

“…IR (cm −1 ) ν: 3367, 1736, 1646, 896. 1 H NMR (600 MHz, in DMSO-d6), δ (ppm): 1.327 (m, 2H, C1-CH 2 ), 2.045 (brs, 1H, C2-CH 2 ), 1.999 (o, 1H, C2-CH 2 ), 3.353 (o, 1H, C3-CH-), 1.463 (o, 1H, C5-CH-), 2.182 (brs, 1H, C6-CH 2 ), 1.987 (brd, J = 6 Hz, 1H, C6-CH 2 ), 2.451 (t, 2H, C7-CH 2 ), 3.506 (o, 1H, C9-CH-), 2.433 (dd, J = 4.2, 2.4 Hz, 2H, C11-CH 2 ), 2.557 (dd, J = 12, 7.2 Hz, 2H, C12-CH 2 ), 7.10 (brs, 1H, C14-CH-), , 4.91 (brs, 2H, C15-CH 2 ), 4.595 (brs, 1H, C17-CH 2 ), 4.455 (brs, 1H, C17-CH 2 ), 1.599 (o, 3H, C18-CH 3 ), 4.207 (brs, 1H, C19-CH 2 ), 4.189 (brs, 1H, C19-CH 2 ), 0.71 (s, 3H, C20-CH 3 ), "o" denotes overlapping signals; 13 (Poonam et al, 2010) of the same compound, AB-2 was unambiguously identified as 14deoxyandrographolide ( Fig. 2).…”

Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2′-N-acetyltransferase in Mycobacterium tuberculosis

“…Recently, other investigators studied the cytotoxic potential of andrographolide on M. microti [24] and M. bovis [25], and reported that it was non-cytotoxic at concentrations at which more than 96% inhibition was observed.…”

Evaluation of relationship between microbial load and drug efficacy of Andrographis paniculata during storage

“…It is widely used as an antidote against poisons of snakes and insect, and as an antimalarial agent (Dua et al, 1999). It is beneficial in general debility, asthma, bronchitis, filariasis and in hepatitis during clinical studies (Kulyal et al, 2010). It has a broad range of pharmacological effects (Roy et al, 2010).…”

“…Literature survey shows wide spectrum of pharmacological activities of kalmegh either in the form of powder, extracts or in its isolated compounds with minimum side effects (Niranjan et al, 2010). About 26 different formulations of this plant are mentioned in Ayurveda as a popular remedy for liver disorders, bowl complaints of children, colic pain, common cold and upper respiratory tract infections (Kulyal et al, 2010;Wen-Wan Chao and Lin, 2010). It is widely used as an antidote against poisons of snakes and insect, and as an antimalarial agent (Dua et al, 1999).…”