ChemInform Abstract: Chiral 1,1′‐Bi(tetrahydroisoquinoline)‐Type Diamines as Efficient Ligands for Nickel‐Catalyzed Enantioselective Michael Addition to Nitroalkenes.

Abstract

Chiral 1,1'-Bi(tetrahydroisoquinoline)-Type Diamines as Efficient Ligands for Nickel-Catalyzed Enantioselective Michael Addition to Nitroalkenes. -Asymmetric Michael addition reaction of malonate (II) towards nitroolefins (I) proceeds with high yields and excellent enantioselectivities (92-99% e.e.) in the presence of a Ni-chiral tetrahydroisoquinoline-based diamine complex. -(WILCKENS, K.; DUHS, M.-A.; LENTZ, D.; CZEKELIUS*, C.; Eur. J. Org. Chem. 2011, 28, 5441-5446, http://dx.