ChemInform Abstract: Chiral Zirconium Alkoxides Mediated Asymmetric Meerwein—Ponndorf—Verley Cyanation of Aldehydes.

Abstract

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Pentafluorobenzaldehyde and its utilizing in organic synthesis

“…Under similar conditions, Meerwein-Pondorf-Verley alkynylation overshoots (Scheme 17 [205,207,208,212]). …”

“…Meerwein-Pondorf-Verley cyanation is based on acetone cyanhydrine utilization [205][206][207][208][209][210] as relatively low-toxic chemical equivalent of hydrogen cyanide, catalysed with Zr(Ot-Bu) 4 . After 10 min, at room temperature, 90% of racemic nitrile of pentafluoromandelic acid was formed (Scheme 16).…”

Chemically Catalyzed Asymmetric Cyanohydrin Syntheses

“…A number of aldehydes were tested under the optimized stoichiometric conditions, with the unusual result that aliphatic systems gave both higher ee values and yields (Scheme , Table 36). 86…”

Synthesis of a Half-Sandwich Hydroxidoiridium(III) Complex Bearing a Nonprotic N-Sulfonyldiamine Ligand and Its Transformations Triggered by the Brønsted Basicity

“…Hydrocyanation using acetone cyanohydrin is an attractive transformation without using hazardous HCN and could be operated without special setups [19,20]. Aside from successful applications in which base and Lewis acid catalysts and biocatalysts have been utilized for transfer hydrocyanation from cyanohydrin to aldehydes [21][22][23][24][25][26][27][28][29][30][31][32][33][34], transition metal-based cyanido complexes can be regarded as potential catalyst candidates to advance the HCN-free process. Scheme 6.…”