ChemInform Abstract: Concise Approach Toward Tetrazolo[1,5‐a][1,4]benzodiazepines via a Novel Multicomponent Isocyanide‐Based Condensation.

Abstract

An efficient procedure is developed with NH4Cl is to give the target compounds in moderate yields.

Concise One-Pot Preparation of Unique Bis-Pyrrolidinone Tetrazoles

“…Exploration of the Ugi–Azide MCR using a variety of diverse reagents have led to the creation of unique scaffolds as exemplified by ketopiperazine–tetrazoles, azepine–tetrazoles, , benzodiazepine–tetrazoles, and quinoxaline–tetrazoles . This letter reports the establishment of unique methodology which utilizes keto-esters (methyl levulinate 2 ), along with primary amines, isocyanides, and TMSN 3 to afford novel peptidomimetic-like bis-pyrrolidinone tetrazoles 3 (Scheme ).…”