ChemInform Abstract: Construction of an All‐Carbon Quaternary Stereocenter by Organocatalytic Enantioselective α‐Functionalization of α‐Substituted β‐Ketocarbonyls with Electron Deficient Vinylarenes.

Abstract

Construction of an All-Carbon Quaternary Stereocenter by Organocatalytic Enantioselective -Functionalization of -Substituted -Ketocarbonyls with Electron Deficient Vinylarenes. -The enantioselective reaction of ketones (II) and (VI) with vinylarenes (I) gives rise to desired dicarbonyl compounds (III) and (VII), which are readily converted into chiral pyrazolones (V) and (VIII), respectively. -(LIU, S.; TONG, M.; YU, Y.; XIE, H.; LI, H.; WANG*, W.; Chem. Commun. (Cambridge) 51 (2015) 56, 11221-11224, http://dx.