ChemInform Abstract: Convenient Method for the Preparation of the 2‐Methyl Thiophen‐3‐yl Magnesium Bromide Lithium Chloride Complex and Its Application to the Synthesis of 3‐Substituted 2‐Methylthiophenes.

Abstract

Convenient Method for the Preparation of the 2-Methyl Thiophen-3-yl Magnesium Bromide Lithium Chloride Complex and Its Application to theSynthesis of 3-Substituted 2-Methylthiophenes. -LiCl significantly accelerates the formation of Grignard reagent from inactive 3-bromo-2-methylthiophene (I) and thus provides access to a variety of 3-substituted 2-methylthiophenes (15 examples). -(KOGAMI, M.; WATANABE*, N.; Synth. Commun. 43 (2013) 5, 681-688, http://dx.