ChemInform Abstract: Curcumin, a Promising Anticancer Therapeutic: A Review of Its Chemical Properties, Bioactivity and Approaches to Cancer Cell Delivery

Salem, Melessa; Rohani, Sohrab; Gillies, Elizabeth R.

doi:10.1002/chin.201428259

Cited by 4 publications

(6 citation statements)

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“…It has various therapeutic properties such as anti-inflammatory, antimicrobial, antitumor, antiparasitic and antioxidant properties [11]. Curcumin possesses anti-inflammatory effects that retard hepatic fibrosis and cirrhosis in carbon tetrachloride (CCl4)-caused liver fibrosis [12].…”

Section: Mini Reviewmentioning

confidence: 99%

Nanoparticulate Carriers of Anticancer Drugs and Therapeutics

Capek

2019

ACRCI

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Section: Mini Reviewmentioning

confidence: 99%

Nanoparticulate Carriers of Anticancer Drugs and Therapeutics

Capek

2019

ACRCI

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“…CUR, chemically 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione is the most widely studied and active component, comprising of monocyclic sesquiterpenes and oxygenated derivatives with a melting point of 183° [ 9] . CUR doesn't dissolve readily in water but dissolves in acetone, methanol and dimethyl sulfoxide.…”

Section: Review Articlementioning

confidence: 99%

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Moselhy¹,

Razvi²,

Hasan³

et al. 2018

pharmaceutical-sciences

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Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

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“…24 Actually, a lower proportion of cancer patients and world's lowest agecorrelated Alzheimer's disease incidences are found in India, and this could be due to the usage of curcumin that has superior beneficial properties. 15,25 Several studies have been conducted, and the anticancer activity of curcumin was established just a decade ago. 19,25,26 Curcumin is a potential choice in the development of drugs and therapeutic agents against several diseases for its broad field of applications.…”

Section: Introductionmentioning

confidence: 99%

“…15,25 Several studies have been conducted, and the anticancer activity of curcumin was established just a decade ago. 19,25,26 Curcumin is a potential choice in the development of drugs and therapeutic agents against several diseases for its broad field of applications. 17,19 Importantly, there are two major challenges which limit their targets.…”

Section: Introductionmentioning

confidence: 99%

Optical Spectroscopic and Morphological Characterizations of Curcuminized Silk Biomaterials: A Perspective from Drug Stabilization

et al. 2017

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Silk protein fibroins have gained remarkable attention in recent years as a potential drug carrier in the developing medicinal field of research. In this work, the stability of anticancer agent curcumin in the presence of two different silk protein fibroins from nonmulberry Antheraea mylitta (Am) and mulberry Bombyx mori (Bm) has been examined, and the possible mechanism of stabilization in a physiologically relevant medium has also been explored. In solution phase, upon treatment with curcumin, the predominated β-sheet structure of Am is marginally altered, whereas in the case of Bm, a substantial structural changeover has been observed (from coil to β-sheet) to accommodate the hydrophobic drug. Also, the morphological assessments suggest that curcumin is nicely housed in the nanoscaffold of silk fibroin (SF). Consequently, the extent of degradation of curcumin is remarkably suppressed upon encapsulation with the SF. The dissimilarity in the binding patterns of curcumin with these silk proteins could be responsible for the observed difference in the stability orders. Curcumin binds the surface of Bm, whereas in Am, the drug is incorporated in the hydrophobic cavity, and as a consequence, the drug is effectively sequestered out of the aqueous medium. The increase in the fluorescence quantum yield upon interaction with the protein greatly modulates the excited-state intermolecular hydrogen atom transfer (ESIPT) process, which is in tune with a substantial increase in the lifetime of the excited-state of curcumin. The ESIPT is known to play a crucial role in the degradation of curcumin under physiological pH conditions, which perhaps implies its potential therapeutic activity in the presence of silk. The in-depth spectroscopic analyses of curcumin–SF complexes in aqueous medium can provide useful insights for further applicative developments in bioengineering.

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ChemInform Abstract: Curcumin, a Promising Anticancer Therapeutic: A Review of Its Chemical Properties, Bioactivity and Approaches to Cancer Cell Delivery

Abstract: Review: 124 refs.

Cited by 4 publications

References 1 publication

Nanoparticulate Carriers of Anticancer Drugs and Therapeutics

Nanoparticulate Carriers of Anticancer Drugs and Therapeutics

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Optical Spectroscopic and Morphological Characterizations of Curcuminized Silk Biomaterials: A Perspective from Drug Stabilization

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