ChemInform Abstract: CYCLISIERUNG VON N‐ACETYL‐N′‐BENZOYL‐O‐PHENYLENDIAMINEN IN DER SCHMELZE

Abstract

Beim Erhitzen der acylierten Phenylendiamine (I) auf 2′25°C entstehen Gemische der Benzimidazole (II) und (III).

Product Class 4: Benzimidazoles

“…[233,234] Refluxing N,N-diacylated 1,2-diaminoarenes 44 in xylene with two equivalents of 4-toluenesulfonic acid results in rapid conversion into 2-substituted benzimidazoles 45 with high yields and purities. The ring closure of diacyl 1,2-diaminoarenes 44 requires higher temperatures than for the monoacyl analogues.…”