ChemInform Abstract: Cytotoxic Activity of 3‐(5‐Phenyl‐3H‐[1,2,4]dithiazol‐3‐yl)chromen‐4‐ones and 4‐Oxo‐4H‐chromene‐3‐carbothioic Acid N‐Phenylamides.

Abstract

Cytotoxic Activity of 3-(5-Phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-Oxo-4H-chromene-3-carbothioic Acid N-Phenylamides. -A series of chromanyl-1,2,4-dithiazoles (I) and N-phenylthioamides (II) respectively is completed using an earlier described synthetic pathway. All compounds are evaluated for their cytotoxic activity against different human cancer cell lines. (Ia) and (Ib) show maximum cytotoxic activity on neuroblastoma whereas (Ic) has cytotoxic activity on ovarian cancer cell line. -(RAJ, T.; BHATIA, R. K.; KAPUR, A.; SHARMA, M.; SAXENA, A. K.; ISHAR*, M. P. S.; Eur. J. Med. Chem. 45 (2010) 2, 790-794; Bio-org. Photochem. Lab., Dep. Pharm. Sci., Guru Nanak Dev Univ., Amritsar 143 005, India; Eng.) -H. Haber

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

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K2CO3: A Mild and Efficient Catalyst for the Synthesis of Pyran Annulated Heterocyclic Systems by Grinding Method Under Solvent-Free Conditions

“…4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds represent an outstanding structural motif well distributed in naturally occurring compounds [3][4][5] with a broad spectrum of considerable biological activities that embrace antimicrobial, 6 anti-inflammatory, 7 antihyperglycemic and antidyslipidemic, 8 anti-HIV [9][10][11] and antimalarial 12,13 .…”

2-(chromon-3-yl)imidazole derivatives as potential antimicrobial agents: synthesis, biological evaluation and molecular docking studies

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