ChemInform Abstract: Dendrimers as Bactericides

Castonguay, Annie; Ladd, Elizabeth; Ven, Theo G. M. van de; Kakkar, Ashok

doi:10.1002/chin.201221263

Cited by 1 publication

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“…Thus, the dendritic scaffold is potentially useful in the design of antimicrobial agents with new mechanism of action. Indeed, numerous organic dendrimers that include glycodendrimers, peptide-based dendrimers, cationic and anionic dendrimers have been described as effective antimicrobial agents; [18][19][20][21][22] however, to our knowledge, an organometallic dendrimer with antimicrobial activity is yet to be reported. Expanding the frontiers of antimicrobial dendrimers to organometallics is, therefore, desirable and represents a strategy towards the design of new antimicrobial agents with new mechanism of action.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Organometallic Dendrimers with Tunable Activity against Multidrug-Resistant Bacteria

et al. 2015

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Multidrug-resistant pathogens are an increasing threat to public health. In an effort to curb the virulence of these pathogens, new antimicrobial agents are sought. Here we report a new class of antimicrobial organometallic dendrimers with tunable activity against multidrug-resistant Gram-positive bacteria that included methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. Mechanistically, these redox-active, cationic organometallic dendrimers induced oxidative stress on bacteria and also disrupted the microbial cell membrane. The minimum inhibitory concentrations, which provide a quantitative measure of the antimicrobial activity of these dendrimers, were in the low micromolar range. AlamarBlue cell viability assay also confirms the antimicrobial activity of these dendrimers. Interestingly, these dendrimers were noncytotoxic to epidermal cell lines and to mammalian red blood cells, making them potential antimicrobial platforms for topical applications.

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Section: Introductionmentioning

confidence: 99%