ChemInform Abstract: Design and Synthesis of 1,4‐Dihydropyridine Derivatives as BACE‐1 Inhibitors.

Multicomponent (MCRs) reactions are classified as one-pot reaction where more than two starting materials are employed to form a single product that contains the building blocks of the starting components. MCRs are considered a convenient approach in synthetic chemistry and have many advantages over the traditional one or two-component reaction, by reducing the number of sequential multiple steps required and often producing better yields. This chapter dissects the use of isocyanide-based MCRs and the elegant chemistry that they offer to build useful scaffolds in the chemical synthetic field. In addition MCRs are considered as one of the recognisable options for increasing “greenness” during the synthesis of pharmaceutical and industrial products.

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The vital use of isocyanide-based multicomponent reactions (MCR) in chemical synthesis

Mohlala

Coyanis

2023

Physical Sciences Reviews

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ChemInform Abstract: Design and Synthesis of 1,4‐Dihydropyridine Derivatives as BACE‐1 Inhibitors.

Abstract: Using structure‐based drug design based on computer‐aided molecular docking, an isophthalamide moiety in a known BACE‐1 inhibitor is replaced by the 1,4‐dihydropyridine (DHP) skeleton with assumed enhanced permeability through the blood‐brain barrier.

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The vital use of isocyanide-based multicomponent reactions (MCR) in chemical synthesis

The vital use of isocyanide-based multicomponent reactions (MCR) in chemical synthesis

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