ChemInform Abstract: Diastereoselective Additions of Titanium Enolates from N‐Glycolyl Thiazolidinethiones to Acetals.

Abstract

Diastereoselective Additions of Titanium Enolates from N-Glycolyl Thiazolidinethiones to Acetals. -The stereoselective outcome of the title reaction is found to depend on the nature of the O-protecting group of glycolate substrate. With pivaloyl protected educts high anti-selectivity can be achieved. The products can smoothly be converted into diverse optically active α,β-dialkoxylated carbonyl compounds such as (VII), which are useful synthetic synthons. -(BAIGET, J.; CABA, M.; GALVEZ, E.; ROMEA*, P.; URPI, F.; FONT-BARDIA, M.; J.