ChemInform Abstract: Diastereoselective Methyl Orthoformate Alkylations of Chiral N‐Acylthiazolidinethiones Catalyzed by Nickel(II) Complexes.

Abstract

Diastereoselective Methyl Orthoformate Alkylations of Chiral N-Acylthiazolidinethiones Catalyzed by Nickel(II) Complexes. -The reaction proceeds with complete diastereoselectivity. The exocyclic bond in the thiazolidinethione auxiliary is required to achieve a high stereocontrol of the reaction and the endocyclic sulfur atom asures that no undesired decomposition takes place. Preliminary results on the extension of the method to the alkylation reaction with different electrophiles are presented. -(ROMO, J. M.; GALVEZ, E.; NUBIOLA, I.; ROMEA*, P.; URPI, F.; KINDRED, M.; Adv. Synth. Catal. 355 (2013) 14-15, 2781-2786, http://dx.