ChemInform Abstract: Diastereoselective Synthesis of Spirocyclic Dihydrofurans and 1‐Oxaspiro[4.5]decan‐6‐one Derivatives from Norbornyl α‐Diketones.

Abstract

Diastereoselective Synthesis of Spirocyclic Dihydrofurans and 1-Oxaspiro[4.5]decan-6-one Derivatives from Norbornyl -Diketones. -Various spirocyclic dihydrofuran structures are prepared in a diastereoselective manner following the sequence shown for (IV) and (VII). Hydrogenation and Grob-type fragmentation leads to the desired, highly functionalized structures (IX) (9 examples). -(MAHADEVEGOWDA, S. H.; KHAN*, F. A.; Eur. J. Org. Chem. 2015, 4, 858-870, http://dx.