ChemInform Abstract: Diastereoselective Synthesis of α‐Tocopherol: A New Concept for the Formation of Chromanols.

Abstract

Vitamins U 0900Diastereoselective Synthesis of α-Tocopherol: A New Concept for the Formation of Chromanols. -An alternative synthesis of α-tocopherol (V) includes 2 key steps: the first is a highly diastereoselective Shi epoxidation of alkene (II) and the second an "anti-Baldwin" epoxide ring opening under inversion of configuration. -(CHAPELAT, J.; BUSS, A.; CHOUGNET, A.; WOGGON*, W.-D.; Org. Lett. 10 (2008) 22, 5123-5126; Dep. Chem., Univ. Basel, CH-4056 Basel, Switz.; Eng.) -Bartels 15-205