ChemInform Abstract: Efficient and Selective Cleavage of the t‐Butoxycarbonyl Group from Di‐t‐butylimidodicarbonate Using Catalytic Bismuth(III) Bromide in Acetonitrile.

Abstract

Deprotection O 0345Efficient and Selective Cleavage of the t-Butoxycarbonyl Group from Di-t-butylimidodicarbonate Using Catalytic Bismuth(III) Bromide in Acetonitrile. -Various amino acid esters and amines (VIII) are selectively mono-deprotected in the presence of BiBr3. The method tolerates the presence of other protecting groups. In the case of cysteine (VI), however, the S-Boc group is also removed. -(ZHENG, J.; YIN, B.; HUANG, W.; LI, X.; YAO, H.; LIU, Z.; ZHANG, J.; JIANG*, S.; Tetrahedron Lett.