ChemInform Abstract: Efficient Post‐Macrocyclization Functionalizations of Oxacalix[2]arene[2]pyrimidines.

Abstract

Efficient Post-Macrocyclization Functionalizations of Oxacalix[2]arene[2]pyrimidines. -Liebeskind-Srogl cross-coupling reaction of (I) with aryl boronic acids is utilized to prepare arylated calixarenes (III). The oxidation of (I) to the corresponding disulfone followed by substitution is optimized for a variety of O-, S-, N-and C-nucleophiles. -(VAN ROSSOM, W.; MAES, W.; KISHORE, L.; OVAERE, M.; VAN MEERVELT, L.; DEHAEN*, W.; Org. Lett. 10 (2008) 4, 585-588; Mol. Des. Synth., Kathol. Univ. Leuven, B-3001 Leuven, Belg.; Eng.) -R. Steudel 30-168