ChemInform Abstract: Efficient Syntheses of (E)‐5‐(2‐Bromovinyl)‐2′‐deoxy‐4′‐thiouridine; a Nucleoside Analogue with Potent Biological Activity.

Abstract

Efficient Syntheses of (E)-5-(2-Bromovinyl)-2'-deoxy-4'-thiouridine; a Nucleoside Analogue with Potent Biological Activity.-Two efficient, alternative routes to the synthesis of the title thiouridine [cf. protected precursors (VII) and (X)], one of the most potent and selective antiherpesvirus compounds known, are developed. -(BASNAK, I.; OTTER, G. P.; DUN-COMBE, R. J.; WESTWOOD, N. B.; PIETRARELLI, M.; HARDY, G. W.; MILLS, G.; RAHIM, S. G.; WALKER, R. T.; Nucleosides Nucleotides 17 (1998) 1-3, 29-38; Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK; EN)