ChemInform Abstract: Efficient Total Synthesis and Biological Activities of 6‐Deoxyisojacareubin.

Abstract

Efficient Total Synthesis and Biological Activities of 6-Deoxyisojacareubin. -6-Deoxyisojacareubin (I) is prepared via a six-step route with an overall yield of about 20%. (I) shows potency in the inhibition of protein kinase C (PKC) and is thought to be of interest as a prospective antitumor agent. -(DAI*, M.; YUAN, X.; ZHU, Z.-J.; SHAN, L.; LIU, R.-H.; SUN, Q.-Y.; ZHANG, W.-D.; Arch. Pharm. (Weinheim, Ger.) 346 (2013) 4, 314-320, http://dx.