ChemInform Abstract: ELECTROCHEMICAL SYNTHESIS OF HETEROCYCLIC COMPOUNDS; VII. ANODIC SYNTHESIS OF 1,3‐THIAZOLE DERIVATIVES

TAVAKOVIC, I.; Trkovnik, M.; Batušić, M.; Tabakovic, Katmerka

doi:10.1002/chin.197949088

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46 Also the electrochemical synthesis of benzothiazoles from N-arylthioamides was reported since 1979. 47,48 Recently, Xu et al 49 Under the optimized reaction conditions, different substrates were converted to the corresponding isoindolinones in 18-96% yield ( Figure 6). The products arise from the addition of the anodically generated amidoyl radical to the double bond and trapping of the generated carbon radical by TEMPO.…”

Section: Dehydrogenative C-s Bond Formation: Synthesis Of Benzothiazomentioning

confidence: 97%

Electroorganic Synthesis under Flow Conditions

2019

View full text Add to dashboard Cite

Despite the long history of electroorganic synthesis, it did not participate in the mainstream of chemical research for long time. This is probably due to the lack of equipment and standardized protocols. However nowadays organic electrochemistry is witnessing a renaissance and a wide range of interesting electrochemical transformations and methodologies has been developed, not only for academic purposes but also for large scale industrial production. Depending on the source of electricity, electrochemical methods can be inherently green, environmentally benign and can be easily controlled to achieve high levels of selectivity. In addition, the generation and consumption of reactive or unstable intermediates and hazardous reagents can be achieved in a safe way. Limitations of traditional batch-type electrochemical methods such as the restricted electrode surface, the necessity of supporting electrolytes and difficulties in scaling up can be alleviated using electrochemical flow cells. Microreactors offer high surface-to-volume ratios and enable precise control over temperature, residence time, flow rate and pressure. In addition, efficient mixing, enhanced mass and heat transfer and handling of small volumes leads to simpler scaling-up protocols and minimize safety concerns. Electrolysis under flow conditions reduces the possibility of overoxidation as the reaction mixture is flown continuously out of the reactor in contrast to traditional batchtype electrolysis cells. In this account, we highlight our contributions in the area of electroorganic synthesis under flow conditions over the past decade. We have designed and manufactured

show abstract