ChemInform Abstract: Ellagi‐ and Gallotannins from Punica granatum Heartwood

El‐Toumy, Sayed A.; Marzouk, Mohamed; Rauwald, H. W.

doi:10.1002/chin.200201185

Cited by 4 publications

(5 citation statements)

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“…The HRESIMS showed a pseudo‐molecular ion peak at m / z 951.18250 [M+H] + (calcd for 951.18313, C 44 H 39 O 24 , Δm −0.63 mDa), corresponding to the molecular formula C 44 H 38 O 24 , which required 26 double bond equivalent (DBE). Its 1H NMR and HSQC spectra showed signals at δ H 7.79 (H‐5“)/δ C 112.2 (C‐5“), 7.76 (H‐5)/112.4 (C‐5), 7.54 (H‐5‘)/112.1 (C‐5‘), and 7.53 (H‐5“‘)/112.1 (C‐5“‘), indicating the existence of two ellagic acid moieties in 11 (Table ) …”

Section: Resultsmentioning

confidence: 99%

Cyclocuneatol and Cuneatannin, New Cycloartane Triterpenoid and Ellagitannin Glycoside from Euphorbia cuneata

et al. 2019

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Phytochemical investigation of the aerial parts of Euphorbia cuneata Vahl. (Euphorbiaceae) revealed new cycloartane triterpenoid, cyclocuneatol (2) and new ellagitannin glycoside, cuneatannin (11), along with nine known metabolites: β‐sitosterol (1), 3β‐hydroxycycloart‐25‐ene‐24‐one (3), cycloart‐25‐ene‐3β,24β‐diol (4), cycloart‐23Z‐ene‐3β,25‐diol (5), 2R‐naringenin (6), β‐sitosterol‐3‐O‐β‐D‐glucopyranoside (7), quercetin (8), kaempferol‐7‐O‐β‐glucoside (9), and 2R‐naringenin‐7‐O‐β‐glucoside (10). Their chemical structures were identified by detailed analyses of physical, chemical, and spectral data as well as comparison with literature. Their cytotoxic activity was assessed towards HepG2, MCF7, and HCT116 cancer cell lines by sulphorhodamine B test (SRB). It is noteworthy that 3 and 4 demonstrated the most significant activity towards HepG2, MCF7, and HCT116 cells (IC50 2.6, 2.7, and 2.4 μM, respectively for 3 and 3.4, 4.1, and 5.3 μM, respectively for 4) in comparison with doxorubicin (IC50 0.18, 0.6, and 0.2 μM, respectively).

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Section: Resultsmentioning

confidence: 99%

Cyclocuneatol and Cuneatannin, New Cycloartane Triterpenoid and Ellagitannin Glycoside from Euphorbia cuneata

et al. 2019

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“…In addition to punicalagin and its isomers, pomegranate contains punicalin A and B and pedunculagin isomers identified by MS and/or NMR. Gallic acid, ellagic acid, caffeic acid, chlorogenic acid, p-coumaric acid, aglycone, and ferulic acid have also been isolated from pomegranate by HPLC and NMR methods [ 25 – 27 ]. Figure 1 shows the main polyphenolic compounds from pomegranate.…”

Section: Chemistry Of P Granatum Fruitmentioning

confidence: 99%

Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials

Eghbali

Askari

Avan

et al. 2021

Journal of Nutrition and Metabolism

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Punica granatum L. belongs to the Punicaceae family which is distributed around the world. Different parts of pomegranate like seed, peel, juice, and leaves are rich in potential bioactive compounds. These plants have found application in traditional medicine such as in treatment of gastrointestinal, cardiovascular, and endocrine diseases, among others. The present review aimed to summarize the current research on the traditional and scientific applications of P. granatum with regard to the phytochemical content and clinical applications that may be useful for future drug development. Information about P. granatum was obtained from local classic herbal literature and electronic databases, such as PubMed, Scopus, and ScienceDirect. Several phytochemical constituents including polyphenolics, flavonoids, anthocyanosides, alkaloids, lignans, and triterpenes have been reported from the plant. Randomized clinical trials have provided evidence as to the pharmacological activities of pomegranate in several diseases including diabetes, cardiovascular disease, oral cavity disorders, endocrine disorders, and cancer. The present review has provided an insight into the traditional applications of the plants, and some of them have been validated by scientific evidence, particularly their applications as treatment of cardiovascular and endocrine diseases.

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“…Punicalagin, punicalin, ellagic acid and ellagic acid derivatives such as 3,3´-di-O-methylellagic acid, 3,3´-tri-O-methylellagic acid, 3´-Omethyl-3,4-methylene, flavonoids like luteolin, quercetin, kaempferol and anthocyanins (delphinidin, cyanidin and pelargonidin), phenolic compounds such as pedunculagin, punicacortein A-D, granatin A and B, punicafolin, punigluconin, corilagin, gallocatechins, several fatty acids, sterols, triterpenes and other tannins have been identified and isolated from various parts of the plant which possess an array of therapeutic properties. [24][25][26][27][28][29][30][31][32][33][34] P. granatum juice contains anthocyanins, glucose, ascorbic acid, ellagic acid, gallic acid, caffeic acid, catechin, epigallocatechin gallate, quercetin, rutin, iron and aminoacids. Punicic acid and sterols are also found in the seed oil of pomegranate.…”

Section: Chemical Constituents and Componentsmentioning

confidence: 99%

An Overview of Phytochemical and Pharmacological Potentials of Punica granatum L

Jacob¹,

Rajiv²,

Gopalan³

et al. 2019

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Punica granatum was formerly classified under a separate family Punicaceae and recently included in Lythraceae family. The family contains genus Punica with two species Punica granatum, commonly known as Pomegranate-the predominant species and Punica protopunica the less predominant species found typically in the island of Socotra. 7 The plant is distributed throughout the world believed to be native to Iran and the Himalayan region. 8 The fruit of this plant is known as nature's power fruit. The plant is an evergreen shrub, with multiple tiny stems. It commonly grows up to 1.8 -4.6 m height. P. granatum is found to have deciduous and shiny leaves which are around 7.6 cm long. The flowers are 5 cm long normally double trumpet-shaped orangered ruffled petals and seen throughout the summer. The fruit is globose with a tough leathery skin with a diameter of around 5-7.6 cm. The mature fruit has reddish or yellowish green shiny skin. The fruit is known as a berry which is composed of spongy membranous walls which contains reddish or whitish pulp with crunchy seeds. The seeds represent around 52% of the entire mass of the fruit. [7][8][9][10] Anatomically, P. granatum can be divided into different parts like seed, juice, peel, leaf, flower, bark and root which exhibits significant pharmacological properties. 11

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ChemInform Abstract: Ellagi‐ and Gallotannins from Punica granatum Heartwood

Abstract: Ellagi-and Gallotannins from Punica granatum Heartwood-[isolation and identification of the new ellagic acid derivatives (I) along with eight known ellagitannins and gallotannins]. -(EL-TOUMY, S. A. A.; MARZOUK, M. S.; RAUWALD, H. W.; Pharmazie 56 (2001) 10, 823-824;

Cited by 4 publications

References 0 publications

Cyclocuneatol and Cuneatannin, New Cycloartane Triterpenoid and Ellagitannin Glycoside from Euphorbia cuneata

Cyclocuneatol and Cuneatannin, New Cycloartane Triterpenoid and Ellagitannin Glycoside from Euphorbia cuneata

Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials

An Overview of Phytochemical and Pharmacological Potentials of Punica granatum L

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