ChemInform Abstract: Enantioselective and Regioselective Indium(III)‐Catalyzed Addition of Pyrroles to Isatins.

Abstract

Enantioselective and Regioselective Indium(III)-Catalyzed Addition of Pyrroles to Isatins. -The reaction requires an excess of pyrrole to provide the addition products with high yields and enantioselectivities. No reaction takes place for the 4-chloroisatin (Ic) although the product is obtained enantioselectively when indole (IV) is used instead of the pyrrole [cf. (V)]. For a pyrrole with 2-substitution, the conditions can control whether a mono-[cf. (XI)] or dipyrrolyloxindole (XII) is formed. -(GUTIERREZ, E. G.; WONG, C. J.; SAHIN, A. H.; FRANZ*, A. K.; Org. Lett. 13 (2011) 21, 5754-5757, http://dx.doi.org/10.1021/ol202329s ; Dep. Chem., Univ. Calif., Davis, CA 95616, USA; Eng.) -R. Steudel