ChemInform Abstract: Enantioselective One‐Pot Organocatalytic Michael Addition/Gold‐Catalyzed Tandem Acetalization/Cyclization.

Abstract

Enantioselective One-Pot Organocatalytic Michael Addition/Gold-Catalyzed Tandem Acetalization/Cyclization. -Although some asymmetric gold-catalyzed cyclizations are known using either chiral ligands or chiral anions, a third alternative strategy is developed consisting of an enantioselective organocatalytic Michael addition to a nitroenyne (II) and a subsequent gold-catalyzed acetalization/cyclization. Organocatalysis and gold catalysis are shown to be compatible and complementary in a one-pot process, thereby enabling isolation of the products in higher yields relative to those for the sequential reaction. -(BELOT, S.; VOGT, K. A.; BESNARD, C.; KRAUSE*, N.; ALEXAKIS, A.; Angew.