ChemInform Abstract: Enantioselective Sulfa‐Michael Addition to α,β‐Unsaturated γ‐Oxoesters Catalyzed by a Metal‐Templated Chiral Broensted Base.

Abstract

Enantioselective Sulfa-Michael Addition to ,-Unsaturated -Oxoesters Catalyzed by a Metal-Templated Chiral Broensted Base. -Substrate (II) is selected as the best educt for the title reaction. Aromatic thiols add to the double bond to form sulfurated products which contain carbonyl groups at the  and  positions in relation to the stereogenic center. The  configuration at the iridium center of the catalyst (I) leads to an (S) configuration of the target thioethers which are of interest as synthons for chiral sulfur-containing pharmaceuticals. -(DING, X.; LIN, H.; GONG*, L.; MEGGERS, E.; Asian J. Org. Chem. 4 (2015) 5, 434-437, http://dx.