ChemInform Abstract: Enantioselective Synthesis of β‐Trifluoromethyl α‐Amino Acids.

Abstract

Enantioselective Synthesis of β-Trifluoromethyl α-Amino Acids. -The structure of the chiral catalysts is essential for the enantioselective hydrogenation of either (Z)-alkyl or (Z)-aryl trifluoroamidoenoates. Enantiopure trifluorovalin is obtained from (IIa). Other selective deprotection reactions of (IIa) are demonstrated. -(BENHAIM*, C.; BOUCHARD, L.; PELLETIER, G.; SELLSTEDT, J.; KRISTOFOVA, L.; DAIGNEAULT, S.; Org. Lett. ; Wyeth Res., St-Laurent, Que. H4R 1J6, Can.; Eng.) -R. Steudel 39-193 s