ChemInform Abstract: Enantioselective Synthesis of α‐Quaternary Amino Acids by Alkylation of Deprotonated α‐Aminonitriles.

Abstract

Enantioselective Synthesis of -Quaternary Amino Acids by Alkylation of Deprotonated -Aminonitriles. -An -alkylation of deprotonated -amino nitriles, prepared from chiral phenyldioxanamine (I) by Strecker reaction, leads to -quaternary arylglycines with high optical purity after hydrolysis and oxidative cleavage of the chiral auxiliary. The procedure requires only chromatographic purification of the final products. -(NETZ, I.; KUCUKDISLI, M.; OPATZ*, T.; J. Org. Chem. 80 (2015) 13, 6864-6869, http://dx.doi.org/10.1021/acs.joc.5b00868 ; Inst. Org. Chem., Johannes-Gutenberg-Univ., D-55128 Mainz, Germany; Eng.) -T. Stabingis 45-092