ChemInform Abstract: First Sequential Mukaiyama—Michael Reaction/Crossed‐Claisen Condensation Using Two Molar Ketene Silyl Acetals and One Molar α,β‐Unsaturated Esters Promoted by a NaOH Catalyst.

Abstract

A sequential Mukaiyama—Michael reaction and regioselective crossed‐Claisen condensation to afford 1,3,7‐tricarbonyl scaffolds is developed using two equivalents of ketene silyl acetals (II)/(IV) and one equivalent α,β‐unsaturated esters (I) in either a stepwise or one‐pot procedure.