ChemInform Abstract: Formation of 5‐Alkylidenepyrazol‐4(1H)‐ones and 3‐Amino‐6‐aryl‐5‐cyanopyridazine‐4‐carboxylates from Arenealdehyde Thiosemicarbazones and Unsaturated 1,2‐Diesters.

Abstract

Pyrazole derivatives R 0180Formation of 5-Alkylidenepyrazol-4(1H)-ones and 3-Amino-6-aryl-5-cyanopyridazine-4-carboxylates from Arenealdehyde Thiosemicarbazones and Unsaturated 1,2-Diesters. -The reaction of arenealdehyde thiosemicarbazones with acetylene dicarboxylates (II) yields pyrazole derivatives of type (III). From the reaction with (IV) pyrazole derivatives of type (V) and pyridazine derivatives of type (VI) are obtained. Possible reaction mechanisms are discussed. -(HASSAN, A. A.; SHEHATA, H. S.; DOEPP*, D.; J. Chem. Res. 2008, 12, 725-730; Fachber. Chem., Univ. Duisburg-Essen, D-45117 Essen, Germany; Eng.) -M. Bohle 21-115