A simple and precise green synthesis method that have been used to synthesis of dihydrtopyrimidinone (DHPMs) and their sulphur analogue dihydropyrimidinthione derivatives traditionally to carry out the conventional Biginelli reaction involves three-component one-pot condensation of an aldehyde, β-ketoester and urea or thiourea in ethanol under strong acidic condensation HCl. The dihydropyrimidinone (DHPMs) and their sulphur analogue dihydropyrimidinthione derivatives which are act as antibacterial, anti-inflammatory, antimalarial agents, and antiviral, antitumor, hypnotic's etc. by green chemistry approach. These reactions were performed by three-component condensation of different types of an aldehyde (benzaldehyde, acetaldehyde, furfural, cinnamaldehyde, and salicaldehyde), ethyl acetoacetate, and urea or thiourea at reflux temperature under solvent-free conditions without catalyst to afford the corresponding dihydropyrimidinones and dihydropyrimidinthione in excellent yields (80-95%). The advantages of this green chemistry approach the excellent yield, short time, operational simplicity, and the avoidance of the use of organic solvents and friendly preparation. Products obtained were identified using physical and spectroscopic IR, 1 HNMR, GC. Mass, UV, techniques.